Mantel-Teeuwisse A.K., Goettsch W.G., Klungel O.H., De Boer A., Herings R.M.C. Long-term statin persistence is poor among high-risk patients with dyslipidemia: a real-world administrative claims analysis. Toth P.P., Granowitz C., Hull M., Anderson A., Philip S. Long-term statin persistence is poor among high-risk patients with baseline peripheral artery disease: a real-world administrative claims analysis of the Optum Research Database. Toth P., Granowitz C., Hull M., Philip S. (Self-Assessment Method for Statin Side-effects Or Nocebo NCT02668016).Ĭrossover trial drug intolerance nocebo side effects statins.Ĭopyright © 2021 The Authors.

Clinicians should not interpret symptom intensity or timing of symptom onset or offset (on starting or stopping statin tablets) as indicating pharmacological causation, because the pattern is identical for placebo. The majority of symptoms caused by statin tablets were nocebo. At 6 months after the trial, 30 of 60 (50%) participants were back taking statins. Stopping was no more frequent for statin than placebo (P = 0.173), and subsequent symptom relief was similar between statin and placebo.

In the individual-patient daily data, neither symptom intensity on starting (OR: 1.02 95% CI: 0.98-1.06 P = 0.28) nor extent of symptom relief on stopping (OR: 1.01 95% CI: 0.98-1.05 P = 0.48) distinguished between statin and placebo. Mean symptom score was 8.0 (95% CI: 4.7-11.3) in no-tablet months. We also measured the 'nocebo' ratio: the ratio of symptoms induced by taking statin that was also induced by taking placebo.Ī total of 60 participants were randomized and 49 completed the 12-month protocol. We measured daily symptom intensity for each using an app (scale 1-100). Participants received 12 1-month medication bottles, 4 containing atorvastatin 20 mg, 4 placebo, and 4 empty. The purpose of this study was to assess daily symptom scores on statin, placebo, and no treatment in participants who had abandoned statins.

Most people who begin statins abandon them, most commonly because of side effects.

Bottle by D.M. Samson